Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling
We demonstrate the capacity and suitability of EPATs for studying the contractile behaviour of human arterial cells and preclinical drug testing. This novel biomimetic platform has the potential to dramatically improve our understanding and treatment of cardiovascular disease.
Authors
- Manuel Mayr (ORCID: https://orcid.org/0000-0002-0597-829X)
- Alexander J. Ainscough (ORCID: https://orcid.org/0000-0001-5293-3898)
- Kate Quigley
- Beata Wójciak‐Stothard (ORCID: https://orcid.org/0000-0002-6607-7372)
- Harry W. Barnett
- Adam Fellows (ORCID: https://orcid.org/0000-0002-9975-3795)
- David M. Miller (ORCID: https://orcid.org/0000-0002-6333-5540)
- Martin R. Wilkins (ORCID: https://orcid.org/0000-0003-3926-1171)
- Vancouver Leung
Institutions
- Imperial College London (GB)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1111/bph.17462
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- British Heart Foundation
- Imperial College London
- National Heart and Lung Institute
- Universitätsklinikum Hamburg-Eppendorf