Intranasal recombinant protein subunit vaccine targeting TLR3 induces respiratory tract IgA and CD8 T cell responses and protects against respiratory virus infection
This work was primarily supported by the European Union Horizon 2020 research and innovation program under grant agreement no. 101003653.
Authors
- Julia Sid Hansen
- Katrine Top Hartmann (ORCID: https://orcid.org/0009-0003-0366-9877)
- Rune Fledelius Jensen
- S. Schmidt (ORCID: https://orcid.org/0000-0002-5631-571X)
- Kenn Holmbeck (ORCID: https://orcid.org/0000-0002-4472-3257)
- Katharina Wørzner (ORCID: https://orcid.org/0000-0002-9430-4229)
- Jens Bukh (ORCID: https://orcid.org/0000-0002-7815-4806)
- Henrik Elvang Jensen (ORCID: https://orcid.org/0000-0001-7277-7829)
- Frank Follmann (ORCID: https://orcid.org/0000-0002-8373-7774)
- Gabriel Kristian Pedersen (ORCID: https://orcid.org/0000-0001-6872-3975)
- Julie Zimmermann (ORCID: https://orcid.org/0000-0001-6442-6439)
- Anna Offersgaard (ORCID: https://orcid.org/0000-0002-7748-2840)
- Santseharay Ramírez (ORCID: https://orcid.org/0000-0003-3699-1814)
- Gitte Erbs (ORCID: https://orcid.org/0000-0003-3764-6473)
- Ida Rosenkrands (ORCID: https://orcid.org/0000-0003-0085-7883)
- Louise Krag Isling
- Carlota Fernandez-Antunez (ORCID: https://orcid.org/0000-0002-3505-4733)
- Judith M. Gottwein (ORCID: https://orcid.org/0000-0003-2805-0256)
- Kristin E. Engelhart Illigen
- Charlotta Polacek (ORCID: https://orcid.org/0000-0003-0297-5672)
- Gregers Jungersen (ORCID: https://orcid.org/0000-0003-3147-6960)
- Ahmad Tami (ORCID: https://orcid.org/0009-0004-7600-9658)
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105615
- Citations
- 7
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- Innovationsfonden
- Moderna
- European Commission
- Gentofte Hospital
- Novo Nordisk
- Novo Nordisk Fonden
- National Institutes of Health
- Danish Agency for Science and Higher Education
- Statens Serum Institut
- H2020 European Research Council