Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis
Mitochondrial ROS contribute to podocyte injury in cystinosis by driving lipid peroxidation and ferroptosis, which in turn lead to podocyte detachment. This finding adds cystinosis to the list of podocytopathies associated with mitochondrial dysfunction. The identified mechanisms reveal new therapeutic targets and highlight lipid peroxidation as an exploitable vulnerability of cystinosis podocytes.
Authors
- Lambertus P. van den Heuvel (ORCID: https://orcid.org/0000-0003-3917-6727)
- Sante Princiero Berlingerio (ORCID: https://orcid.org/0000-0001-9274-7360)
- Tjessa Bondue (ORCID: https://orcid.org/0000-0003-1952-6400)
- Fanny Oliveira Arcolino (ORCID: https://orcid.org/0000-0003-2207-9699)
- Marc Fransen (ORCID: https://orcid.org/0000-0001-9284-1197)
- Angela Ferrulli (ORCID: https://orcid.org/0000-0002-5774-6351)
- Sara Cairoli (ORCID: https://orcid.org/0000-0002-5925-0974)
- Sarah Tassinari (ORCID: https://orcid.org/0000-0001-6297-8010)
- Elena Levtchenko (ORCID: https://orcid.org/0000-0002-8352-7312)
- Bart Ghesquière (ORCID: https://orcid.org/0000-0003-1547-1705)
- Florian Siegerist (ORCID: https://orcid.org/0000-0003-1629-4982)
- Bianca Maria Goffredo (ORCID: https://orcid.org/0000-0001-9933-3240)
- Benedetta Bussolati (ORCID: https://orcid.org/0000-0002-3663-5134)
- Nicole Endlich (ORCID: https://orcid.org/0000-0001-6817-4099)
- Celien Lismont (ORCID: https://orcid.org/0000-0002-7388-8878)
Institutions
- Radboud University Nijmegen (NL)
- Universitätsmedizin Greifswald (DE)
- Radboud University Medical Center (NL)
- Emma Kinderziekenhuis (NL)
- Bambino Gesù Children's Hospital (IT)
- Amsterdam University Medical Centers (NL)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12967-024-05996-w
- Citations
- 6
- Primary Topic
- Biomedical Research and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Fonds Wetenschappelijk Onderzoek
- Horizon 2020
- Universitaire Ziekenhuizen Leuven, KU Leuven