Whole exome sequencing identified mutations of forkhead box I 1 (FOXI1), keratin 6 C (KRT6C) and gap junction protein delta 2 (GJD2) in a low-grade oncocytic tumor of the kidney: a case report
We report three mutations in genes that have not been previously reported in LOT of the kidney. The genes are not related to the mTOR pathway. Therefore, LOT of the kidney might occur through several mechanisms and/or include several types of renal oncocytic tumors.
Authors
- Koichi Nishimura (ORCID: https://orcid.org/0000-0003-0651-7484)
- Daisuke Toki
- Akinari Kakumoto
- Rika Kasajima (ORCID: https://orcid.org/0000-0001-6389-6594)
- Yohei Miyagi (ORCID: https://orcid.org/0000-0002-0056-7010)
- Hajime Kuroda (ORCID: https://orcid.org/0000-0001-6546-5317)
- Tsunenori Kondo (ORCID: https://orcid.org/0000-0002-9130-0855)
- Yoji Nagashima
- Atsuko Masunaga (ORCID: https://orcid.org/0000-0002-4904-2995)
Institutions
- Kanagawa Prefectural Hospital Organization (JP)
- Tokyo Women's Medical University Hospital (JP)
- Tokyo Women's Medical University Adachi Medical Center (JP)
- Tokyo Women's Medical University (JP)
- Kanagawa Cancer Center
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s13000-025-01616-3
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tokyo Women's Medical University