Bone Marrow CD8 + Abundance Inversely Correlates with Progressive Marrow Fibrosis and Myelodysplastic Evolution in GATA2 Deficiency: Case Report
Providing a long-term follow-up of one GATA2-deficient patient, we suggest that a decrease in BM CD8+ T cells may serve as an early marker of immune surveillance escape and disease progression. These findings underscore the need for further investigation into the role of BM CD8+ T cells in GATA2 deficiency and MDS evolution, potentially offering new insights for follow-up and therapeutic intervention.
Authors
- Francesca Vendemini (ORCID: https://orcid.org/0000-0003-1818-2757)
- Marco Chiarini (ORCID: https://orcid.org/0000-0003-1000-0461)
- Vincenzo L’Imperio (ORCID: https://orcid.org/0000-0002-9284-2998)
- Oscar Maglia
- Grazia Fazio (ORCID: https://orcid.org/0000-0001-7077-8422)
- Francesco Saettini (ORCID: https://orcid.org/0000-0003-0767-3905)
- Fabiola Guerra (ORCID: https://orcid.org/0000-0002-2018-6813)
- Rocco Piazza (ORCID: https://orcid.org/0000-0003-4198-9620)
- Andrea Biondi (ORCID: https://orcid.org/0000-0002-6757-6173)
- Sonia Bonanomi
- Federica Mottadelli
- Simona Sala (ORCID: https://orcid.org/0000-0001-6357-0375)
- Samuele Roncareggi (ORCID: https://orcid.org/0009-0002-0413-7998)
Institutions
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1007/s10875-025-01871-5
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 3.54