Therapeutic evaluation of Wumei Pill (WP) for nocturnal asthma in Bmal1 gene knockout mice
The knockout of the Bmal1 gene, a crucial regulator of circadian rhythms, disrupts the circadian expression of inflammatory chemokines. Treatment with WP modulated Bmal1 expression, influencing the release of these mediators, offering a promising strategy for managing nocturnal asthma. Notably, wild-type nocturnal asthma mice exhibited significantly better control of airway inflammation compared to their Bmal1-deficient counterparts, highlighting the importance of circadian regulation in the pathophysiology of asthma.
Authors
- Yunwei Chen (ORCID: https://orcid.org/0000-0002-5144-925X)
- Yili Tao
- Ying Yang (ORCID: https://orcid.org/0000-0002-0087-2648)
- Po Hu
- Bohan Wang (ORCID: https://orcid.org/0000-0003-1065-5011)
- Ye Wu (ORCID: https://orcid.org/0000-0002-6770-6767)
- Kun Wang (ORCID: https://orcid.org/0000-0003-4221-2485)
- Weiping Mei
Institutions
- Nanjing University of Chinese Medicine (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Asthma
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1080/02770903.2025.2469317
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China