The phenogenomic landscapes of pleural mesothelioma tumor microenvironment predict clinical outcomes
Our findings underscore the intricate interplay between the tumor genome, TME composition, and clinical outcomes in MPM. These data support the potential of integrating genomic and TME profiling to develop more precise patient stratification strategies and potentially optimize therapeutic approaches, including immunotherapy.
Authors
- Benedetta Apollonio (ORCID: https://orcid.org/0000-0003-2414-5549)
- Andrea Billè (ORCID: https://orcid.org/0000-0003-4709-4174)
- Cynthia Bishop (ORCID: https://orcid.org/0009-0006-1104-596X)
- Alessia Ciarrocchi (ORCID: https://orcid.org/0000-0002-5541-2075)
- Richard J. Ellis (ORCID: https://orcid.org/0000-0002-7459-8485)
- Nedyalko Petrov (ORCID: https://orcid.org/0000-0003-1873-5542)
- Filomena Spada (ORCID: https://orcid.org/0000-0002-8063-3953)
- Federica Torricelli (ORCID: https://orcid.org/0000-0003-1954-5695)
- Katrina Todd (ORCID: https://orcid.org/0000-0003-0208-3359)
- Daisuke Nonaka (ORCID: https://orcid.org/0000-0002-5719-9765)
- Alan G. Ramsay (ORCID: https://orcid.org/0000-0002-0452-0420)
- Manuela Terranova Barberio
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Istituto Tumori Bari (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12967-025-06193-z
- Citations
- 2
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Guy's and St Thomas' Charity