Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR)
Our multi-omics data, although performed in a relatively small cohort of patients, revealed new systemic biological elements involved in the pathogenesis of CAMR and identified CHI3L1 as a new potential biomarker and/or therapeutic target for this important clinical complication. Future validation of these findings in larger patient cohorts should be conducted to better evaluate their clinical utility.
Authors
- Loreto Gesualdo (ORCID: https://orcid.org/0000-0002-4861-0911)
- Martina Bartolucci (ORCID: https://orcid.org/0000-0001-5289-4219)
- Simona Granata (ORCID: https://orcid.org/0000-0002-3740-7598)
- Giovanni Candiano (ORCID: https://orcid.org/0000-0002-7385-2787)
- Paola Pontrelli (ORCID: https://orcid.org/0000-0002-7654-8318)
- Francesca Leone (ORCID: https://orcid.org/0009-0001-6640-8290)
- Sonia Spinelli (ORCID: https://orcid.org/0000-0001-9847-4308)
- Gianluigi Zaza (ORCID: https://orcid.org/0000-0002-6004-6196)
- Laura Barberio
- Andrea Petretto (ORCID: https://orcid.org/0000-0001-7811-8517)
- Maurizio Bruschi
Institutions
- Istituto Giannina Gaslini (IT)
- Ospedale Annunziata di Cosenza (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Calabria (IT)
- University of Bari Aldo Moro (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12967-025-06203-0
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99
Funders
- European Commission
- Ministero della Salute