Ac-225 radiochemistry through the lens of [225Ac]Ac-DOTA-TATE
The quality of Ac-225 labeled DOTA-radiopharmaceuticals is highly dependent on the pH and stabilization (buffer/quencher). Within this research it is demonstrated that optimized quality control methods and accurate measurement of the radiolabeling kinetics are crucial to ensure safe implementation for patient treatment.
Authors
- Yann Seimbille (ORCID: https://orcid.org/0000-0002-9736-5318)
- Erik de Blois (ORCID: https://orcid.org/0000-0002-0659-7819)
- Aliyah Morgenstern (ORCID: https://orcid.org/0000-0001-8440-2186)
- Carolline Ntihabose
- Frank Bruchertseifer (ORCID: https://orcid.org/0000-0003-2125-4483)
- Tessa Brabander (ORCID: https://orcid.org/0000-0002-8000-6490)
- J. R. de Jong
- Stijn L.W. Koolen (ORCID: https://orcid.org/0000-0002-0973-7530)
- Eline Hooijman
Institutions
- TRIUMF (CA)
- Erasmus MC (NL)
- Joint Research Centre (DE)
- Erasmus MC Cancer Institute (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s41181-025-00332-z
- Citations
- 12
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 16.32
Funders
- Erasmus Medisch Centrum