Efficacy of avocado seed extract in preventing, inhibiting, and eliminating Prevotella intermedia biofilms: An in vitro study

Avocado seed ethanol extract demonstrated significant antibiofilm properties against <i>P. intermedia</i>, comparable to chlorhexidine at higher concentrations. The bioactive compounds - flavonoids, tannins, saponins, and alkaloids - likely contributed to these effects through mechanisms such as quorum sensing inhibition, disruption of bacterial adhesion, and destabilization of biofilm structures. These findings highlight avocado seed extract as a promising natural alternative for managing periodontitis-related biofilm infections.