SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic Synergy
In TP53 and KRAS double-mutated pancreatic cancer, SMURF2-driven GAP17-1 membrane expulsion facilitates mutant p53-KRAS oncogenic synergy.
Authors
- Shirish Shukla
- Dipankar Ray (ORCID: https://orcid.org/0000-0002-1297-2312)
- Shirish M. Gadgeel (ORCID: https://orcid.org/0000-0001-5240-3811)
- Dafydd G. Thomas (ORCID: https://orcid.org/0000-0002-0379-7460)
- Katelyn L. Donahue (ORCID: https://orcid.org/0000-0001-9535-9275)
- Srimathi Kasturirangan (ORCID: https://orcid.org/0000-0001-6472-0283)
- Yaqing Zhang (ORCID: https://orcid.org/0000-0002-9185-4364)
- Theodore S. Lawrence (ORCID: https://orcid.org/0000-0002-4186-8821)
- Derek J. Nancarrow (ORCID: https://orcid.org/0000-0002-7470-7194)
- Marina Pasca di Magliano (ORCID: https://orcid.org/0000-0001-9632-9035)
- Kyle Clifford Cuneo (ORCID: https://orcid.org/0000-0002-8264-6483)
- Paramita Ray (ORCID: https://orcid.org/0000-0003-0036-064X)
- Sunita Shankar (ORCID: https://orcid.org/0000-0001-8743-7480)
Institutions
- Henry Ford Health System (US)
- University of Michigan (US)
- Michigan United (US)
- Institute of Cytology and Preventive Oncology (IN)
- U-M Rogel Cancer Center (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-0701
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05