Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response
Airway eosinophilia marks a subset of COPD patients with increased airway epithelial expression of type 2 inflammation and a response to ICS treatment.
Authors
- Ji‐Yong Moon (ORCID: https://orcid.org/0000-0003-2459-3448)
- Stephan F. van Eeden (ORCID: https://orcid.org/0000-0002-7224-8852)
- Stephen Lam (ORCID: https://orcid.org/0000-0002-3964-1492)
- Hiroto Takiguchi (ORCID: https://orcid.org/0000-0001-9540-374X)
- Kei Yamasaki (ORCID: https://orcid.org/0000-0003-1876-3287)
- Yu Ji Cho (ORCID: https://orcid.org/0000-0002-0247-802X)
- Stephen B Milne (ORCID: https://orcid.org/0000-0001-5274-1298)
- Graeme J. Koelwyn (ORCID: https://orcid.org/0000-0002-3476-0919)
- Rachel L. Eddy (ORCID: https://orcid.org/0000-0002-2541-1645)
- Don D. Sin (ORCID: https://orcid.org/0000-0002-0756-6643)
- Tawimas Shaipanich (ORCID: https://orcid.org/0000-0001-5551-0073)
- Clarus Leung (ORCID: https://orcid.org/0000-0003-3515-7537)
- Min Hyung Ryu (ORCID: https://orcid.org/0000-0003-3071-7363)
- Kentaro Akata
- Seung Won (ORCID: https://orcid.org/0000-0003-1764-7890)
- Hye Yun Park (ORCID: https://orcid.org/0000-0002-5937-9671)
- Seyed Milad Vahedi (ORCID: https://orcid.org/0000-0002-5846-2107)
- Josie Tuong
- Xuan Li (ORCID: https://orcid.org/0009-0004-1337-3049)
- Hyun Kuk Kim (ORCID: https://orcid.org/0000-0002-9360-3956)
- Fernando Sergio Leitão Filho (ORCID: https://orcid.org/0000-0002-0064-7002)
- J.S.W. Yang
- Janice M. Leung (ORCID: https://orcid.org/0000-0003-1682-6483)
Institutions
- Ulsan College (KR)
- University of British Columbia Hospital (CA)
- BC Cancer Agency (CA)
- The University of Sydney (AU)
- Tokai University (JP)
- University of British Columbia (CA)
- Simon Fraser University (CA)
- University of Occupational and Environmental Health Japan (JP)
- Samsung Medical Center (KR)
- University of Ulsan (KR)
- Gyeongsang National University Hospital (KR)
- Konkuk University Medical Center (KR)
- Inje University Haeundae Paik Hospital (KR)
- Ulsan University Hospital (KR)
- St. Paul's Hospital (CA)
- Sungkyunkwan University (KR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1183/13993003.01875-2024
- Citations
- 15
- Primary Topic
- Pediatric health and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 37.75
Funders
- AstraZeneca Canada
- British Columbia Lung Association
- Canadian Institutes of Health Research