Bimetallic MOF doped with reduced graphene oxide enables rapid detection of chloramphenicol

Abstract A broad-spectrum antibiotic called chloramphenicol (CAP) stops the creation of bacterial proteins, which stops bacteria from growing and reproducing. When chloramphenicol is misused, it can cause major side effects, secondary infections, bacterial resistance, delays in effective treatment, and higher treatment costs. As a result, creating an electrochemical sensor that is quick and sensitive is crucial. The electrocatalytic activity of CAP determination was enhanced in this work by producing reduced graphene oxide doped bimetallic organic framework (Fe/Al-MOF/rGO) nanocomposites in a single pot, which had more active sites and better electrical conductivity. The constructed sensor has a linear range of 20 - 1600 μM and a detection line (LOD) of 1.5 nM (S/N=3). Furthermore, the sensor’s recovery rate for sample detection is good enough.