Distinct mural cells and fibroblasts promote pathogenic plasma cell accumulation in idiopathic pulmonary fibrosis
Plasma cells and local antibodies are widely distributed in the fibrotic regions of IPF lungs. Distinct subsets of IPF-associated mural cells and fibroblasts promote pathological plasma cell and antibody accumulation. These findings have potential implications for strategies aimed at targeting immune and antibody responses to combat IPF.
Authors
- Gaoyuan Cao (ORCID: https://orcid.org/0000-0001-8308-7401)
- Steven S. An (ORCID: https://orcid.org/0000-0003-4723-1888)
- Joseph A. Jude (ORCID: https://orcid.org/0000-0003-3083-0489)
- S. Orfanos (ORCID: https://orcid.org/0000-0002-8229-8562)
- Qi Yang (ORCID: https://orcid.org/0000-0002-8365-0986)
- Xiaosheng Tan (ORCID: https://orcid.org/0000-0001-9920-1555)
- Dianhua Jiang (ORCID: https://orcid.org/0000-0002-4508-3829)
- Reynold A. Panettieri (ORCID: https://orcid.org/0000-0003-0834-4636)
- Gaëtan Barbet (ORCID: https://orcid.org/0000-0002-0152-3650)
- Zhi Yang (ORCID: https://orcid.org/0000-0002-4198-5809)
Institutions
- Rutgers, The State University of New Jersey (US)
- Cedars-Sinai Medical Center (US)
- Johnson University (US)
- Lung Institute (US)
- Zero to Three (US)
- Qi2 (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1183/13993003.01114-2024
- Citations
- 11
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 16.70