Flecainide Intoxication

Flecainide is among the most prescribed antiarrhythmic medications and is used to effectively treat recurrent arrhythmia and maintain normal sinus rhythm by acting as a sodium channel blocker. However, its potent effects and narrow therapeutic window pose increasing risks of flecainide intoxication and ensuing morbidity and mortality. Here we report an unusual case of suicide by intentional flecainide overdose. This case demonstrates the importance of early recognition and treatment in avoiding the adverse consequences of flecainide intoxication, and it also demonstrates the importance of appropriate use and safe storage of flecainide.

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Publication Details

Journal
American Journal of Forensic Medicine & Pathology
Published
2025-02-20
DOI
https://doi.org/10.1097/paf.0000000000001026
Citations
1
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
1.39
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article

Flecainide Intoxication

Kevin Norton, Shu-min Fan
1 citations
American Journal of Forensic Medicine & Pathology
Cardiac electrophysiology and arrhythmias
1.39
article

Flecainide Intoxication

Kevin Norton, Shu-min Fan
article en
1 citations

Abstract

Flecainide is among the most prescribed antiarrhythmic medications and is used to effectively treat recurrent arrhythmia and maintain normal sinus rhythm by acting as a sodium channel blocker. However, its potent effects and narrow therapeutic window pose increasing risks of flecainide intoxication and ensuing morbidity and mortality. Here we report an unusual case of suicide by intentional flecainide overdose. This case demonstrates the importance of early recognition and treatment in avoiding the adverse consequences of flecainide intoxication, and it also demonstrates the importance of appropriate use and safe storage of flecainide.

American Journal of Forensic Medicine & PathologyVol. 46(3)
University of Missouri (US), University of Toledo (US)
Good health and well-being
Openalex Percentile: Top 22%
Cardiac electrophysiology and arrhythmias
1.39
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