Performance of 8 Smoking Metrics for Modeling Survival in Head and Neck Squamous Cell Carcinoma
In this cohort study, smoking duration and log cig-years best modeled a linear relationship with OS for patients with HNSCC. Both metrics maintained robust performance within specific clinicodemographic subgroups and anatomic subsites. Although most HNSCC survival models control for smoking exposure using smoking status or pack-years, duration and log cig-years may be superior metrics to account for the effects of smoking on survival.
Authors
- Andrew C. L. Lam (ORCID: https://orcid.org/0000-0001-6923-2721)
- Paul Brennan (ORCID: https://orcid.org/0000-0002-0518-8714)
- Miranda Pring (ORCID: https://orcid.org/0000-0003-4658-5772)
- D. Neil Hayes
- Antonio Agudo (ORCID: https://orcid.org/0000-0001-9900-5677)
- Stacey A. Santi
- Wolfgang Ahrens (ORCID: https://orcid.org/0000-0003-3777-570X)
- Martha Pienkowski (ORCID: https://orcid.org/0000-0002-8953-1080)
- Katrina Hueniken (ORCID: https://orcid.org/0000-0003-1376-8046)
- Shama Virani (ORCID: https://orcid.org/0000-0002-1163-432X)
- David I. Conway (ORCID: https://orcid.org/0000-0001-7762-4063)
- Rayjean J. Hung (ORCID: https://orcid.org/0000-0002-4486-7496)
- Gary J. Macfarlane (ORCID: https://orcid.org/0000-0003-2322-3314)
- Cristina Canova (ORCID: https://orcid.org/0000-0001-7027-7935)
- Ariana Znaor
- Mari Nygård (ORCID: https://orcid.org/0000-0002-4100-4855)
- Claire M. Healy (ORCID: https://orcid.org/0000-0003-0583-6360)
- Areti Lagiou (ORCID: https://orcid.org/0000-0002-6687-358X)
- Tim Waterboer (ORCID: https://orcid.org/0000-0002-0616-6963)
- Brenda Diergaarde (ORCID: https://orcid.org/0000-0002-3578-6547)
- Deborah Saunders (ORCID: https://orcid.org/0000-0001-9499-4488)
- Jerry Polesel (ORCID: https://orcid.org/0000-0001-9381-1520)
- Anna Horňáková (ORCID: https://orcid.org/0000-0002-1024-8056)
- Mei Dong (ORCID: https://orcid.org/0000-0003-1735-5361)
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
- Wei Xu (ORCID: https://orcid.org/0000-0002-1337-0620)
- Jong Wook Lee (ORCID: https://orcid.org/0000-0002-3364-9960)
- Michael Conlon (ORCID: https://orcid.org/0000-0003-4815-8125)
- Lorenzo Richiardi
- Laia Alemany
- P. Lagiou (ORCID: https://orcid.org/0000-0001-7877-6253)
- A.F. Olshan
Institutions
- University of North Carolina at Chapel Hill (US)
- Norwegian Institute of Public Health (NO)
- University of Padua (IT)
- University of Tennessee Health Science Center (US)
- German Cancer Research Center (DE)
- University of Bremen (DE)
- University of Toronto (CA)
- University of Aberdeen (GB)
- National and Kapodistrian University of Athens (GR)
- Trinity College Dublin (IE)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Charles University (CZ)
- Heidelberg University (DE)
- University Of Bristol Dental Hospital (GB)
- Princess Margaret Cancer Centre (CA)
- Health Sciences North (CA)
- University of Bristol (GB)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- University of West Attica (GR)
- Institut Català d'Oncologia (ES)
- Northeast Cancer Centre (CA)
- Leibniz Institute for Prevention Research and Epidemiology - BIPS (DE)
- Public Health Ontario (CA)
- UPMC Hillman Cancer Center (US)
- Centro di Riferimento Oncologico (IT)
- Cancer Registry of Norway (NO)
- Sinai Health System (CA)
- Center for Cancer Research (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Centre international de recherche sur le cancer (FR)
- University of Turin (IT)
- University of Glasgow (GB)
- NOSM University (CA)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1001/jamaoto.2024.5392
- Citations
- 3
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.54