Pain Intensity in Patients with Opioid Use Disorder on Extended-Release Naltrexone or Opioid Agonists; The Role of COMT rs4680 and OPRM1 rs1799971: An Exploratory Study
The wild-type allele Val/Val of COMT rs4680 and the rare allele G of OPRM1 rs1799971 may have a possible protective effect regarding pain intensity in patients with OUD receiving OAT. Given relatively low sample size, particularly low number of female participants in the XR-NTX group and other possible confounders, our findings should be interpreted with caution.
Authors
- Jon Mordal (ORCID: https://orcid.org/0009-0006-9868-2450)
- Ann‐Christin Sannes (ORCID: https://orcid.org/0000-0002-3918-8149)
- Kristin Klemmetsby Solli (ORCID: https://orcid.org/0000-0003-4622-2947)
- Lars Tanum (ORCID: https://orcid.org/0000-0003-4001-6325)
- Bente Margrethe Weimand (ORCID: https://orcid.org/0000-0003-1800-7318)
- Farid Juya (ORCID: https://orcid.org/0009-0008-6522-0473)
- Johannes Gjestad
Institutions
- OsloMet – Oslo Metropolitan University (NO)
- Akershus University Hospital (NO)
- Høyskolen Kristiania (NO)
- University of South-Eastern Norway (NO)
- Sykehuset i Vestfold (NO)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jpr.s500984
- Citations
- 1
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 2.19
Funders
- Norges Forskningsråd
- Helse Sør-Øst RHF