Quality of life and clinical data in hemodialysis patients with different degrees of pruritus

Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, its possible association with selected solutes, and impact on quality of life (QoL) in hemodialysis patients. Involving 434 hemodialysis patients in Spain, this observational study employed a survey based on validated pruritus assessment tools, alongside demographic, clinical, and biochemical data collection. The study used statistical analyses to examine the correlation between CKD-aP and various QoL dimensions. CKD-aP affected 46,4% (202) of the participants, with no significant variation across gender and age (p = 0.222 and p = 0.379, respectively). There were no significant associations between CKD-aP and biochemical markers like calcium, phosphate, and C-reactive protein (p > 0.05, in all cases). Each reporting period (morning, midday, evening, and night) revealed distinct patterns in pruritus prevalence and severity (p < 0.05). The nighttime report exhibited the most significant differences, as more than half of the patients with moderate to severe pruritus reported constant and frequent itching (23.0% and 27.9%, respectively). Concerning other variables and symptoms associated with QoL, pruritus group exhibited higher rates of anxiety, depression, decreased sexual desire and sexual function, and sometimes to most of the time reported sleep onset problems, sleeping pill use, and drowsiness on waking (p < 0.001 in all cases). When stratifying by pruritus intensity differences persisted across anxiety (p < 0.001) and sleep onset problems (p = 0.018). The findings underscore the high prevalence and severe impact of CKD-aP in QoL among hemodialysis patients, indicating a need for standardized screening and treatment approaches in clinical practice. The lack of correlation with common biochemical markers suggests an intricate pathophysiology, warranting further investigation. These insights emphasize the necessity of holistic management strategies and more research to understand CKD-aP complex nature for better patient outcomes.

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Publication Details

Journal
Scientific Reports
Published
2025-02-20
DOI
https://doi.org/10.1038/s41598-024-83833-2
Citations
2
Primary Topic
Dermatology and Skin Diseases
Type
article
Field-Weighted Citation Impact
4.01
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article

Quality of life and clinical data in hemodialysis patients with different degrees of pruritus

Guillermo Alcalde Bezhold, Ángel Méndez, Emilio Sánchez-Álvarez, Marc Handel Blanc et al.
2 citations
Scientific Reports
Dermatology and Skin Diseases
4.01
article

Quality of life and clinical data in hemodialysis patients with different degrees of pruritus

Guillermo Alcalde Bezhold, Ángel Méndez, Emilio Sánchez-Álvarez, Marc Handel Blanc, Margarita Delgado, Nuria Aresté-Fosalba, Juan M. Guerrero, Mario Prieto‐Velasco, María Jesús Lloret, Marina Burgos da Silva, Elena Guerrero, Rosa Elena Pérez-Morales, Dolores Piña Simón, Ana Botella Lorenzo, Alicia González Horna, Marián Goicoechea, Pablo Molina, Marta San Juan, Mara Lisbet Cabana, Delfina Yetman, Karina Ruth Furaz Czerpak, Paula Manso, Juan Manuel Buades, Vicent Esteve Simó, Rafáel Sánchez, María Melissa Vasquez, Sebastián Mas, Mónica Pereira, Fabiola Dapena, Ana Blanco Santos, Damián Carneiro, Carlos F. Narváez, L. Colino, María Dolores Arenas Jiménez, David Hernán Gascueña, Julia Audije-Gil, María Luz Sánchez, R. Garcia, Raquel Ojeda, Cristina Ledesma Torre, Ana Ma Sacristán
article en
2 citations

Abstract

Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, its possible association with selected solutes, and impact on quality of life (QoL) in hemodialysis patients. Involving 434 hemodialysis patients in Spain, this observational study employed a survey based on validated pruritus assessment tools, alongside demographic, clinical, and biochemical data collection. The study used statistical analyses to examine the correlation between CKD-aP and various QoL dimensions. CKD-aP affected 46,4% (202) of the participants, with no significant variation across gender and age (p = 0.222 and p = 0.379, respectively). There were no significant associations between CKD-aP and biochemical markers like calcium, phosphate, and C-reactive protein (p > 0.05, in all cases). Each reporting period (morning, midday, evening, and night) revealed distinct patterns in pruritus prevalence and severity (p < 0.05). The nighttime report exhibited the most significant differences, as more than half of the patients with moderate to severe pruritus reported constant and frequent itching (23.0% and 27.9%, respectively). Concerning other variables and symptoms associated with QoL, pruritus group exhibited higher rates of anxiety, depression, decreased sexual desire and sexual function, and sometimes to most of the time reported sleep onset problems, sleeping pill use, and drowsiness on waking (p < 0.001 in all cases). When stratifying by pruritus intensity differences persisted across anxiety (p < 0.001) and sleep onset problems (p = 0.018). The findings underscore the high prevalence and severe impact of CKD-aP in QoL among hemodialysis patients, indicating a need for standardized screening and treatment approaches in clinical practice. The lack of correlation with common biochemical markers suggests an intricate pathophysiology, warranting further investigation. These insights emphasize the necessity of holistic management strategies and more research to understand CKD-aP complex nature for better patient outcomes.

Scientific ReportsVol. 15(1)
Hospital Universitario La Paz (ES), Hospital General Universitario Gregorio Marañón (ES), Hospital Son Llatzer (ES), Hospital Universitario Nuestra Señora de Candelaria (ES), Hospital Universitario Virgen Macarena (ES), Consorci Sanitari de Terrassa (ES), Fundación Española de la Nutrición (ES), Hospital Universitario Araba (ES), Hospital Universitario Reina Sofía (ES), Health Research Institute of the Balearic Islands (ES), Hospital Universitario Doctor Peset (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Puigvert Foundation (ES), Hospital Universitario De Cabueñes (ES), Complejo Asistencial Universitario de Palencia (ES), Fundación Renal Española (ES)
Openalex Percentile: Top 8%
Dermatology and Skin Diseases
4.01
DOIOpen Access PDFOpenAlex
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