Supplement-Induced Acute Kidney Injury Reproduced in Kidney Organoids
These findings provide the first evidence suggesting that certain toxicants in specific batches of Beni-koji CholesteHelp supplements cause direct renal tubular injury. This KS cell-based organoid system represents a cost-effective, reproducible, and technically simple platform for nephrotoxicity screening.
Authors
- Jun Wada (ORCID: https://orcid.org/0000-0003-1468-5170)
- Shinji Kitamura (ORCID: https://orcid.org/0000-0003-4535-8092)
- Kenji Tsuji (ORCID: https://orcid.org/0000-0001-5442-7008)
- Soichiro Haraguchi
- Hiroyuki Nakanoh
- Kazuhiko Fukushima (ORCID: https://orcid.org/0000-0001-8651-2733)
Institutions
- Okayama University (JP)
- Okayama Prefectural University (JP)
- Akebono Clinic (JP)
- Okayama Psychiatric Medical Center (JP)
Publication Details
- Journal
- American Journal of Nephrology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1159/000544795
- Citations
- 8
- Primary Topic
- Muscle and Compartmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 16.05
Funders
- Wesco Science Foundation
- Japan Society for the Promotion of Science