Optimal Frequency for Seizure Induction With Electroconvulsive Therapy and Magnetic Seizure Therapy in Nonhuman Primates
While neither efficacy nor side effects were assessed in this study, the results highlight the significance of stimulus frequency for seizure induction, suggest efficient titration schedules that minimize exposure to the electrical stimulus, and can inform studies to assess the impact on clinical outcomes. These data can also support safety guidelines for interventions such as transcranial magnetic stimulation that must avoid seizure induction.
Authors
- Zhi‐De Deng (ORCID: https://orcid.org/0000-0001-8925-0871)
- Christopher Sikes-Keilp
- Elyssa Feuer (ORCID: https://orcid.org/0009-0002-9392-1708)
- Sarah H. Lisanby (ORCID: https://orcid.org/0000-0003-2037-6470)
- Angel V. Peterchev (ORCID: https://orcid.org/0000-0002-4385-065X)
- Moacyr Alexandro Rosa (ORCID: https://orcid.org/0000-0002-3492-0548)
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- Universidade de São Paulo (BR)
- National Institute of Mental Health (US)
- National Institute of Mental Health (CZ)
- University of Toledo (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100471
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- MagVenture
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke