Anterior Versus Posterior Lumbar Interbody Fusion at L5-S1 in Hybrid Surgery for Adult Spinal Deformity: A Propensity Score Matching Analysis of Radiographic Results, Mechanical Complications, and Clinical Outcomes

<b>Objectives</b>: The aim of this study was to compare the radiographic results, mechanical complications, and clinical outcomes between anterior and posterior lumbar interbody fusion at L5-S1 (ALIF51 and PLIF51 groups, respectively) using a matched cohort of patients undergoing long fusion for adult spinal deformity (ASD). <b>Methods</b>: Patients who underwent hybrid surgery of ≥5-level fusion to the pelvis with a minimum follow-up duration of 2 years were included. The baseline characteristics of the groups were controlled using a propensity score matching analysis. The radiographic results, mechanical complications such as proximal junctional kyphosis/failure and metal failure, and clinical outcomes were compared between the groups. <b>Results</b>: In total, 79 patients were assigned to each group with comparable baseline data, except for a higher frequency of anterior column realignment procedures in the PLIF51 group than in the ALIF51 group (49.4% vs. 31.6%). At the last follow-up, L5-S1 segmental lordosis (SL) was significantly greater in the ALIF51 group than in the PLIF51 group (12.1° vs. 7.3°, <i>p</i> < 0.001). The final C7-sagittal vertical axis (SVA) was significantly smaller in the ALIF51 group than in the PLIF51 group (25.4 mm vs. 35.5 mm, <i>p</i> = 0.032). However, other global sagittal parameters were comparable between the groups. The mechanical complication rates, including metal failure at L5-S1, and the final clinical outcomes were comparable between the groups. <b>Conclusions</b>: ALIF51 has modest advantages over PLIF51 in terms of better restoring L5-S1 SL and C7-SVA with avoiding more invasive procedures above the L5-S1 levels. Other sagittal parameters, mechanical complication rates, and clinical outcomes did not differ between the groups.