Identifying Baicalein as a Key Bioactive Compound in XueBiJing Targeting KEAP1: Implications for Antioxidant Effects
These findings collectively establish baicalein as a critical bioactive compound in XBJ, driving its antioxidant and anti-inflammatory effects via KEAP1/NRF2 pathway activation through direct binding to KEAP1, providing new insights into the mechanism of action of XBJ.
Authors
- Hsi‐Yuan Huang (ORCID: https://orcid.org/0000-0001-8453-4939)
- Yuanjia Hu
- Jihang Chen (ORCID: https://orcid.org/0000-0003-0738-1777)
- Hua‐Li Zuo (ORCID: https://orcid.org/0000-0002-0359-2481)
- Hsien‐Da Huang
- Kunmeng Liu
- Shangfu Li
- Jie Ni (ORCID: https://orcid.org/0000-0002-8844-6132)
- Ting-Xuan Lin (ORCID: https://orcid.org/0000-0002-7274-4100)
- Yang-Chi-Dung Lin (ORCID: https://orcid.org/0000-0003-2436-4602)
- Jing Li (ORCID: https://orcid.org/0000-0001-7792-4322)
- Liping Li (ORCID: https://orcid.org/0000-0002-2994-6583)
- Yibing Wang
- Yi-Gang Chen (ORCID: https://orcid.org/0009-0008-7290-0047)
- Zihao Zhu (ORCID: https://orcid.org/0000-0003-2768-8477)
- Xiaoxuan Cai
- Junyao Xiao
- Jiatong Xu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University of Macau (MO)
- Peking Union Medical College Hospital (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-02-20
- DOI
- https://doi.org/10.3390/antiox14030248
- Citations
- 5
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 6.97
Funders
- National Natural Science Foundation of China
- Chinese University of Hong Kong
- Shenzhen Fundamental Research Program