Whole-genome bisulfite sequencing of cell-free DNA unveils age-dependent and ALS-associated methylation alterations
cfDNA methylation is a powerful tool for assessing age-related changes and ALS-specific molecular dysregulation by revealing perturbed locus, genes, and the proportional contributions of different tissues/cells to the plasma. This technique holds promise for clinical application in biomarker discovery across a broad spectrum of neurodegenerative disorders.
Authors
- Karen N. Conneely (ORCID: https://orcid.org/0000-0002-1994-6934)
- Emily G. Allen (ORCID: https://orcid.org/0000-0003-0963-036X)
- Teepu Siddique (ORCID: https://orcid.org/0000-0001-7293-9146)
- Sandra Guingrich
- Peng Jin (ORCID: https://orcid.org/0000-0001-6137-6659)
- Robert K. Naviaux (ORCID: https://orcid.org/0000-0001-5832-2297)
- Robert M. Pascuzzi (ORCID: https://orcid.org/0000-0003-0616-3073)
- Wenjing Ma (ORCID: https://orcid.org/0000-0001-8757-651X)
- Yulin Jin (ORCID: https://orcid.org/0000-0002-7142-5589)
Institutions
- Northwestern University (US)
- Emory University (US)
- University of Michigan (US)
- University of California San Diego (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s13578-025-01366-1
- Citations
- 8
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- National Institutes of Health
- University of California, San Diego
- National Institute of Neurological Disorders and Stroke
- National Institute of Child Health and Human Development