A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults
In this setting, HBV sequence polymorphisms and deletions are associated with HCC, and 'non-T53 + G1764A' represents a putative signature motif for HCC. Additional investigations are needed to disaggregate the impact of other demographic, clinical, and environmental influences, to ascertain the extent to which viral polymorphisms contribute to oncogenesis, and to determine whether HBV sequence is a useful biomarker for HCC risk stratification.
Authors
- Haiting Chai (ORCID: https://orcid.org/0000-0003-0558-3965)
- Monique Andersson (ORCID: https://orcid.org/0000-0003-0619-1074)
- David Bonsall (ORCID: https://orcid.org/0000-0003-2187-0550)
- Camilla L. C. Ip
- Jolynne Mokaya (ORCID: https://orcid.org/0000-0001-8398-0689)
- Richard H. Glashoff
- Jason T. Blackard (ORCID: https://orcid.org/0000-0003-2876-3811)
- Philippa Clare Matthews (ORCID: https://orcid.org/0000-0002-4036-4269)
- Sheila Lumley (ORCID: https://orcid.org/0000-0001-6825-9324)
- Anna McNaughton (ORCID: https://orcid.org/0000-0002-7436-8727)
- Anna Kramvis (ORCID: https://orcid.org/0000-0001-6006-3765)
- Cori Campbell (ORCID: https://orcid.org/0000-0001-5890-7105)
- Elizabeth Waddilove (ORCID: https://orcid.org/0000-0003-3228-3845)
- Tongai Maponga (ORCID: https://orcid.org/0000-0002-6876-3712)
- M. Azim Ansari (ORCID: https://orcid.org/0000-0003-2790-8353)
- Wolfgang Preiser (ORCID: https://orcid.org/0000-0002-0254-7910)
- Christo Van Rensburg
- Mariateresa de Cesare
Institutions
- University of the Witwatersrand (ZA)
- Stellenbosch University (ZA)
- The Francis Crick Institute (GB)
- Wellcome Sanger Institute (GB)
- Tygerberg Hospital (ZA)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Oxford BioMedica (United Kingdom) (GB)
- University College London (GB)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Annals of Hepatology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1016/j.aohep.2024.101763
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Francis Crick Institute
- University College London Hospitals Biomedical Research Centre