Corticosteroid premedication on anti-tumor effect of immune checkpoint blockade in murine hepatocellular carcinoma models
Corticosteroid premedication does not significantly compromise anti-tumor efficacy of dICB treatment in murine HCC models. These results suggest that clinical investigations of prophylactic corticosteroids to alleviate severe irAEs may be feasible.
Authors
- Ann‐Lii Cheng (ORCID: https://orcid.org/0000-0002-9152-6512)
- Ying‐Chun Shen (ORCID: https://orcid.org/0000-0001-8426-9071)
- Chia‐Lang Hsu (ORCID: https://orcid.org/0000-0002-7447-8045)
- Da‐Liang Ou (ORCID: https://orcid.org/0000-0002-8368-1141)
- Ching-Ping Yeh
- Wan-Ying Lin (ORCID: https://orcid.org/0000-0002-2616-9133)
- Nai-Wen Chang (ORCID: https://orcid.org/0009-0003-6176-8785)
- Ming‐Feng Wei (ORCID: https://orcid.org/0000-0002-1796-1049)
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-009704
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Bristol-Myers Squibb
- Ministry of Science and Technology, Taiwan
- National Taiwan University
- National Science and Technology Council