An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots
The smoking-associated metabolites and pathway perturbations that we identified suggested inflammatory responses and have also been implicated in chronic diseases of the central nervous system and the lung. Our results suggest that infant metabolism in the early postnatal period reflects smoking specific physiologic responses to maternal smoking with strong biologic plausibility.
Authors
- Karan Uppal (ORCID: https://orcid.org/0000-0001-5985-1668)
- Dean P. Jones (ORCID: https://orcid.org/0000-0002-2090-0677)
- Di He
- Julia E. Heck (ORCID: https://orcid.org/0000-0001-8713-8413)
- Douglas I. Walker (ORCID: https://orcid.org/0000-0003-2912-398X)
- Qi Yan (ORCID: https://orcid.org/0000-0003-4418-123X)
- Beate Ritz (ORCID: https://orcid.org/0000-0001-6976-7339)
Institutions
- University of North Texas (US)
- Emory University (US)
- UCLA Health (US)
- Université Bourgogne Franche-Comté (FR)
- Fielding Graduate University (US)
Publication Details
- Journal
- Metabolomics
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1007/s11306-025-02225-3
- Citations
- 1
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Tobacco-Related Disease Research Program
- National Institutes of Health