PARP9 exacerbates apoptosis and neuroinflammation via the PI3K pathway in the thalamus and hippocampus and cognitive decline after cortical infarction
Our findings demonstrate that PARP9 aggravates neural damage and cognitive decline after cerebral infarction by promoting neuronal apoptosis and neuroinflammation, partly via the PI3K pathway.
Authors
- Weixian Huang (ORCID: https://orcid.org/0000-0001-9995-2631)
- Jiaqi An
- Mengshi Liao (ORCID: https://orcid.org/0000-0001-5570-2657)
- Yuhua Fan (ORCID: https://orcid.org/0000-0002-1172-1490)
- Xiangming Xu
- Yicong Chen (ORCID: https://orcid.org/0000-0002-3907-7991)
- Xiya Long
Institutions
- Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12974-025-03374-x
- Citations
- 11
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 11.50
Funders
- National Natural Science Foundation of China
- Guangzhou Science and Technology Program key projects