Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway
The present study demonstrated that MLT alleviates age-related lacrimal dysfunction in mice and humans via the SIRT-1/NLRP3 pathway. MLT alleviated the inflammatory response and the decline in the secretory function of the aged lacrimal gland.
Authors
- Mingchang Zhang (ORCID: https://orcid.org/0000-0003-1886-8572)
- Hua-Tao Xie (ORCID: https://orcid.org/0000-0003-4027-691X)
- Huan Guo (ORCID: https://orcid.org/0000-0001-8146-3573)
- Suna Zhou (ORCID: https://orcid.org/0000-0002-4233-9200)
- Chao Wang (ORCID: https://orcid.org/0000-0002-7460-7628)
- Yuzhi Li (ORCID: https://orcid.org/0000-0001-9062-8085)
- Xi Peng (ORCID: https://orcid.org/0000-0003-1898-9964)
- Jia-Song Wang
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1167/iovs.66.2.51
- Citations
- 4
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 7.51