Construction of 2‐(Trifluoromethyl)‐[1,2,4]Triazolo[1,5‐<i>a</i>]Quinoline Derivatives via Cycloaddition of <i>N</i>‐Amino Quinolinium Salts with CF<sub>3</sub>CN
Abstract A (3+2)‐cycloaddition of N ‐amino quinolinium salts with in situ generated trifluoroacetonitrile is disclosed. The reaction affords access to structurally diverse 2‐(trifluoromethyl)‐[1,2,4]triazolo[1,5‐ a ]quinoline derivatives in good yields, utilizing 2,2,2‐trifluoroacetaldehyde O ‐(aryl)oxime as precursor of trifluoroacetonitrile.
Authors
- Shouxiong Chen
- Zhiqiang Weng (ORCID: https://orcid.org/0000-0001-6851-1841)
- Fafu Yang (ORCID: https://orcid.org/0000-0002-0825-5329)
- Peiqi Yang (ORCID: https://orcid.org/0009-0007-1720-7912)
- Z. Chen
Institutions
- Fujian Normal University (CN)
- Minjiang University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1002/ajoc.202500010
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.79