Formulation and Assessment of Punica External Gel for Gallic Acid Composition and Anti-microbial Research

Soxhlet was used to extract the evaporated, crushed the Punica granatum peel with water acting as a solvent. Topical formulation gels containing different combinations of polymers and Punica aqueous extract were assessed for their antibacterial effectiveness, viscosity, spread ability, gallic acid concentration (as determined by HPLC), and physicochemical characteristics. The gel was effectively prepared and assessed for both the gallic acid content (3.5%) and the medicinal properties of the formulation. The in-house Punica gel had the strongest antimicrobial action against B. subtilis, P. aeruginosa, K. pneumoniae, and A. Nigeria, while the gel also exhibited outstanding antibacterial and antifungal activity.