USE OF IMMUNOMODULATOR FOR MASTITIS IN COWS

The purpose of the research is the development of optimal dose of “Immunofarm” preparation for treatment of serous mastitis in high-yielding cows. To conduct research, 4 groups of 10 animals each were formed from cows diagnosed with serous mastitis on the basis of clinical examination of the mammary gland and milk reaction to Masttest. The drug “Immunopharm” was administered intracisternally at intervals of 72 hours until the disappearance of symptoms of serous mastitis. The first experimental group of ani-mals was administered the drug in a dose of 5.0 ml, the 2nd experimental group of animals was administered the drug in a dose of 10.0 ml, the 3rd experimental group of animals was administered the drug in a dose of 15.0 ml. The control group of animals was treated with the drug “Mastisan” in a dose of 5.0 ml with an interval of 24 hours. The use of the preparation “Immunofarm” at a dose of 10.0 ml intracisternally into the mammary gland with an interval of 24 hours contributes to the fading of the inflammatory pro-cess: normalization of local temperature occurs 1.95 days earlier, the disappearance of udder soreness appears 2.43 days earlier, the absence of clots and flakes in the milk is reduced by 1.35 days, the recovery of milk productivity comes 1.43 days earlier com-pared to the control. No significant difference was found between the indicators of using the preparation “Immunofarm” in the dose of 10.0 ml and 15.0 ml. Duration of treatment in animals of the 2nd experimental group is 2.90 days less, the treatment efficiency is 20.0% more. The use of the optimal dose of “Immunofarm” provides earlier normalization of acidity, milk density, somatic cell con-tent, increasing the milk productivity of overdosed animals by 7.90 kg of milk.