ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound
A medical needle driven by continuous US waves at 32.2 kHz has the capability of disassembling a duplex oligonucleotide and enhancing released ASOs internalization into articular cartilage. This work offers the potential delivery and the local triggered release of ASOs at the surface of articular cartilage providing potential benefits for the treatment of diverse cartilage pathologies.
Authors
- Maxime Fauconnier (ORCID: https://orcid.org/0000-0001-8713-5036)
- Marwa Elkhashab (ORCID: https://orcid.org/0000-0001-6386-7849)
- Heikki J. Nieminen (ORCID: https://orcid.org/0000-0001-6084-1272)
- Kenneth A. Howard (ORCID: https://orcid.org/0000-0002-9407-278X)
- Laura B. Creemers (ORCID: https://orcid.org/0000-0002-1585-3052)
- Gonçalo Barreto (ORCID: https://orcid.org/0000-0003-4444-9208)
- Yohann Le Bourlout (ORCID: https://orcid.org/0000-0002-8296-334X)
Institutions
- University of Helsinki (FI)
- Aarhus University (DK)
- University Medical Center Utrecht (NL)
- Invalidisäätiö (FI)
- Aalto University (FI)
Publication Details
- Journal
- Drug Delivery
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1080/10717544.2025.2464921
- Citations
- 1
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Academy of Finland