Integrated Seroprevalence and Genome‐Based Study of SARS‐CoV‐2 Viral Strains in N′Djamena: Insights Into Chad's COVID‐19 Epicenter
The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.
Authors
- Giulia Cappelli (ORCID: https://orcid.org/0000-0002-5353-5549)
- Nathan Naïbeï
- Djallaye Djimtoïbaye
- Issifou Yaya (ORCID: https://orcid.org/0000-0002-2554-6515)
- Andrillene Laure Deutou Wondeu (ORCID: https://orcid.org/0000-0003-4303-8474)
- Sabrina Atturo (ORCID: https://orcid.org/0000-0001-7646-9006)
- Mahamat Fayiz Abakar (ORCID: https://orcid.org/0000-0003-1412-2503)
- Guy R. Takoudjou Dzomo (ORCID: https://orcid.org/0000-0002-2660-5396)
- Vittorio Colizzi
- Fissou Henry Yandai
- D. Ben Abdallah (ORCID: https://orcid.org/0000-0001-6168-0781)
- Oumaima Djarma (ORCID: https://orcid.org/0000-0002-0695-4417)
- Franck J. D. Mennechet (ORCID: https://orcid.org/0000-0001-6036-930X)
- Marta Giovanetti (ORCID: https://orcid.org/0000-0002-5849-7326)
- Yanda Mberkissam Daniel
- Fatima Abdelrazakh
- Choua Ouchemi
- Koutaya Dezoumbe (ORCID: https://orcid.org/0009-0003-7759-4134)
- Abdoulaye Boukar
- Netalar Honorine
- Kayanlengar Frederic
- Mahamat Grene
- Noubaramadji Yamti Suitombaye
- Amine Akouya
- Adam Moussa Alim
- Choroma Ahmat Moussa
- Mahamat Idriss Hamad
- Mahamat Ali Moussa
- N. Armand
- Ali Moustapha
- Mathiew Hota
- Zongo R. F. Edgard
Institutions
- University of Rome Tor Vergata (IT)
- University of N'Djamena (TD)
- Inserm (FR)
- Università Campus Bio-Medico (IT)
- Université de Montpellier (FR)
- African Palliative Care Association (UG)
- Centre International De Reference Chantal Biya (CM)
- Université de Sarh (TD)
- Université de Moundou (TD)
- Association Sahélienne de Recherche Appliquée pour le Développement Durable (TD)
- Institut Universitaire Polytechnique de Mongo (TD)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jmv.70234
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Agenzia Italiana per la Cooperazione allo Sviluppo