Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study
Carbohydrate antigen 19-9 after induction therapy, carbohydrate antigen 19-9 decrease, and performance status are independent prognostic factors for overall survival after surgical exploration for locally advanced pancreatic cancer. Three-year overall survival is best in patients with a performance status of zero, a greater than 80% decrease in carbohydrate antigen 19-9, and a post-induction carbohydrate antigen 19-9 level less than 50 U/ml.
Authors
- Alice C. Wei (ORCID: https://orcid.org/0000-0002-2505-959X)
- L.R. Prakash
- Roeland F. de Wilde (ORCID: https://orcid.org/0009-0003-0444-8697)
- David van Klaveren (ORCID: https://orcid.org/0000-0002-2096-606X)
- Crisanta Ilagan (ORCID: https://orcid.org/0000-0001-7013-0634)
- Matthew H. G. Katz (ORCID: https://orcid.org/0000-0003-3870-6968)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Dana Haviland
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Alessandro Paniccia (ORCID: https://orcid.org/0000-0001-7047-1711)
- Sarah J. McIntyre (ORCID: https://orcid.org/0000-0002-0234-1541)
- Amer H. Zureikat (ORCID: https://orcid.org/0000-0002-7800-5464)
- Quisette P. Janssen (ORCID: https://orcid.org/0000-0002-9353-8293)
- Amila O. De Silva (ORCID: https://orcid.org/0000-0002-5126-8854)
- Eileen Mary O'Reilly (ORCID: https://orcid.org/0000-0002-8076-9199)
- Ching‐Wei D. Tzeng (ORCID: https://orcid.org/0000-0001-6035-7288)
- Esther N. Dekker (ORCID: https://orcid.org/0000-0002-3040-6736)
- Eva M M Verkolf
- Rutger T. Theijse
- Rudy El Asmar
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Erasmus MC (NL)
- University of Pittsburgh Medical Center (US)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- British journal of surgery
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1093/bjs/znaf011
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- ZonMw
- KWF Kankerbestrijding