Cigarette Smoking Induces Skeletal Muscle Atrophy in Mice by Activated Macrophage-Mediated Pyroptosis
TNF-α released by CSE-activated macrophages can promote skeletal muscle pyroptosis by activating the TNFR1/NLRP3/Caspase-1/GSDMD signaling pathway, which likely contributes to skeletal muscle atrophy. These findings provide more insight into the mechanisms underlying skeletal muscle atrophy in COPD.
Authors
- Enyuan Qin (ORCID: https://orcid.org/0000-0001-8494-4831)
- Yi Tan (ORCID: https://orcid.org/0000-0003-0789-0926)
- Lihua Huang (ORCID: https://orcid.org/0000-0002-3575-5417)
- Guo-Lin Xiong
- Xinyan Wei (ORCID: https://orcid.org/0000-0002-2946-3928)
- Jie Li (ORCID: https://orcid.org/0000-0003-2343-1658)
- Yuanyuan Ye
- Tong Liang
- C.H. Huang
- Y. Bin (ORCID: https://orcid.org/0000-0001-9118-9854)
Institutions
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s497631
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.84