Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts
Early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD) patients showed distinct and overlapping cortical atrophy patterns. EOAD patients showed prominent atrophy in widespread neocortical regions. LOAD patients showed prominent atrophy in the anterior medial temporal lobe. Regional atrophy was correlated with the severity of global cognitive impairment. Results were comparable when the sample was stratified for mild cognitive impairment (MCI) and dementia.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Stephen Salloway (ORCID: https://orcid.org/0000-0002-2631-0942)
- Michael Brickhouse
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Alireza Atri (ORCID: https://orcid.org/0000-0003-4405-6973)
- Angelina J. Polsinelli (ORCID: https://orcid.org/0000-0002-7738-9574)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Daniel R. Schonhaut
- Julien Lagarde (ORCID: https://orcid.org/0000-0002-2018-261X)
- Alexander Taurone
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Erik S. Musiek (ORCID: https://orcid.org/0000-0002-8873-0360)
- Ian Grant (ORCID: https://orcid.org/0000-0001-6960-6762)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Sharon Sha
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Bernardino Ghetti (ORCID: https://orcid.org/0000-0002-1842-8019)
- Tatiana Foroud
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kyle Womack (ORCID: https://orcid.org/0000-0002-6060-9075)
- Laurel Beckett (ORCID: https://orcid.org/0000-0002-2418-9843)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Kathy L. Newell (ORCID: https://orcid.org/0000-0002-1648-7357)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Ranjan Duara (ORCID: https://orcid.org/0000-0001-8060-6309)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Raymond Scott Turner (ORCID: https://orcid.org/0000-0001-7534-2935)
- Ryan Eckbo
- Neill R. Graff‐Radford (ORCID: https://orcid.org/0000-0001-9847-9096)
- Alexander Zaitsev
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Paul Aisen
- Maryanne Thangarajah
- Meghan Riddle
- Rema Reman
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Alzheimer's Association (US)
- Autism Research Institute (US)
- Houston Methodist (US)
- Mayo Clinic (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Mount Sinai Medical Center (US)
- Methodist Hospital (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- Weill Cornell Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14489
- Citations
- 8
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.45
Funders
- Alzheimer's Association
- National Institutes of Health