Association of late‐life variability in hemoglobin A1C with postmortem neuropathologies
Hemoglobin A1C (A1C), a measure of peripheral insulin resistance, is used to assess glycemic control. Higher A1C mean was associated with greater odds of macroscopic subcortical infarcts. A1C variability was not associated with cerebrovascular pathology. Both A1C mean and variability had inverse associations with AD pathology. None of the associations varied by diabetes mellitus status.
Authors
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Roshni Biswas (ORCID: https://orcid.org/0000-0003-1938-1256)
- Rupal I. Mehta (ORCID: https://orcid.org/0000-0003-4917-6907)
Institutions
- Rush University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14471
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Institutes of Health
- National Institute on Aging