Low‐Magnitude High‐Frequency Vibration Attenuates Sarcopenia by Modulating Mitochondrial Quality Control via Inhibiting miR‐378
Our findings indicate that mitochondrial biogenesis, fusion, fission, and mitophagy were compromised during progression of sarcopenia, with mitochondrial deterioration preceding the onset of sarcopenia symptoms. The study also demonstrated that LMHFV could attenuate sarcopenia by modulating mitochondrial quality control through inhibiting miR-378, highlighting its therapeutic potential in the management of age-related muscular degeneration.
Authors
- Wing‐Hoi Cheung (ORCID: https://orcid.org/0000-0003-3247-8255)
- Elvis Chun‐Sing Chui (ORCID: https://orcid.org/0000-0003-4195-6773)
- Ronald Man Yeung Wong (ORCID: https://orcid.org/0000-0001-5615-6627)
- Christoph Brochhausen (ORCID: https://orcid.org/0000-0002-6761-0247)
- Simon Kwoon‐Ho Chow (ORCID: https://orcid.org/0000-0003-1742-980X)
- Zhen Xu (ORCID: https://orcid.org/0000-0001-6985-2277)
- Yufeng Long
- Dazhi Yang (ORCID: https://orcid.org/0000-0003-0316-8346)
- Qianjin Wang (ORCID: https://orcid.org/0000-0003-1474-0918)
- Clinton T. Rubin (ORCID: https://orcid.org/0000-0003-0909-7999)
- Can Cui (ORCID: https://orcid.org/0000-0001-9328-4521)
- Ling Qin (ORCID: https://orcid.org/0000-0001-6173-6167)
- Rebecca Schoenmehl
- Ning Zhang (ORCID: https://orcid.org/0000-0002-9513-9288)
- Gang Li (ORCID: https://orcid.org/0000-0002-7436-5227)
Institutions
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Shenzhen University Health Science Center (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Stony Brook University (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13740
- Citations
- 5
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province