Amniotic fluid-derived exosomal miR-146a-5p ameliorates preeclampsia phenotypes by inhibiting HIF-1α/FLT-1 expression
The study provided experimental evidence for the protective effects of normal AF-Exos on ameliorating preeclampsia phenotypes, and miR-146a-5p may act an important role in enhancing the proliferation and migration of trophoblast cells by targeting HIF-1α.
Authors
- Lu Wan (ORCID: https://orcid.org/0000-0003-4624-5524)
- Jing Lin (ORCID: https://orcid.org/0000-0002-4405-134X)
- Weiming Yang (ORCID: https://orcid.org/0000-0002-5023-2155)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4700-6907)
- Xiaozhong Wang (ORCID: https://orcid.org/0000-0002-3500-3856)
- Bo Huang (ORCID: https://orcid.org/0000-0003-1327-6586)
- Xiaohong Huang (ORCID: https://orcid.org/0000-0003-4809-4010)
- Fan Sun (ORCID: https://orcid.org/0000-0002-9689-3573)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Placenta
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1016/j.placenta.2025.02.013
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 6.17