Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models

Our data strongly corroborate and extend our understanding of the direct pathogenic and epileptogenic role of human LGI1 autoantibodies.

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Publication Details

Journal
Brain Behavior and Immunity
Published
2025-02-20
DOI
https://doi.org/10.1016/j.bbi.2025.02.019
Citations
3
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
4.17

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article

Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models

Gavin L. Woodhall, Arunvir Atwal, Jack O'Brien-Cairney, Alexander Stumpf et al.
3 citations
Brain Behavior and Immunity
Autoimmune Neurological Disorders and Treatments
4.17
article

Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models

Gavin L. Woodhall, Arunvir Atwal, Jack O'Brien-Cairney, Alexander Stumpf, Sukhvir Wright, Max A Wilson, Masaki Fukata, Jakob Kreye, Scott van Hoof, Divya Dhangar, Harald Prüß, Jan Henje Döring, Hans‐Christian Kornau, César Cordero Gómez, Susanne G. Mueller, Yuko Fukata, Manoj A. Upadhya, Richard Rosch, Philipp Boehm‐Sturm, Dietmar Schmitz, Julius Hoffmann
article en
3 citations

Abstract

Our data strongly corroborate and extend our understanding of the direct pathogenic and epileptogenic role of human LGI1 autoantibodies.

Brain Behavior and ImmunityVol. 126
Aston University (GB), National Institutes of Natural Sciences (JP), German Center for Neurodegenerative Diseases (DE), Humboldt-Universität zu Berlin (DE), King's College Hospital NHS Foundation Trust (GB), National Institute for Physiological Sciences (JP), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE)
Japan Agency for Medical Research and Development, Wellcome Trust, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Aston University, Helmholtz Association
Zero hunger
Openalex Percentile: Top 7%
Autoimmune Neurological Disorders and Treatments
4.17
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