Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models
Our data strongly corroborate and extend our understanding of the direct pathogenic and epileptogenic role of human LGI1 autoantibodies.
Authors
- Gavin L. Woodhall (ORCID: https://orcid.org/0000-0003-1281-9008)
- Arunvir Atwal
- Jack O'Brien-Cairney
- Alexander Stumpf
- Sukhvir Wright (ORCID: https://orcid.org/0000-0002-5464-3779)
- Max A Wilson (ORCID: https://orcid.org/0000-0003-3317-9433)
- Masaki Fukata (ORCID: https://orcid.org/0000-0001-5200-9806)
- Jakob Kreye (ORCID: https://orcid.org/0000-0003-2913-1015)
- Scott van Hoof (ORCID: https://orcid.org/0000-0002-2091-0904)
- Divya Dhangar
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Jan Henje Döring
- Hans‐Christian Kornau (ORCID: https://orcid.org/0000-0003-4187-7549)
- César Cordero Gómez
- Susanne G. Mueller (ORCID: https://orcid.org/0000-0002-5053-2211)
- Yuko Fukata (ORCID: https://orcid.org/0000-0001-7724-8643)
- Manoj A. Upadhya (ORCID: https://orcid.org/0000-0002-2032-1472)
- Richard Rosch (ORCID: https://orcid.org/0000-0002-0316-5818)
- Philipp Boehm‐Sturm (ORCID: https://orcid.org/0000-0001-8777-4823)
- Dietmar Schmitz (ORCID: https://orcid.org/0000-0003-2741-5241)
- Julius Hoffmann (ORCID: https://orcid.org/0000-0001-6576-8158)
Institutions
- Aston University (GB)
- National Institutes of Natural Sciences (JP)
- German Center for Neurodegenerative Diseases (DE)
- Humboldt-Universität zu Berlin (DE)
- King's College Hospital NHS Foundation Trust (GB)
- National Institute for Physiological Sciences (JP)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1016/j.bbi.2025.02.019
- Citations
- 3
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Japan Agency for Medical Research and Development
- Wellcome Trust
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Aston University
- Helmholtz Association