Klebsiella pneumoniae urinary tract infection: A multicentric study highlights significant regional variations in antimicrobial susceptibility across India

Oral treatment options for <i>K. pneumoniae</i> cystitis are rapidly decreasing. Northern and southern India showed significant differences in antimicrobial susceptibility, highlighting the importance of local antibiograms for promoting antimicrobial stewardship. For uncomplicated cystitis, co-trimoxazole (54%) may be the empirical choice. Good susceptibility to fosfomycin was observed (89%). The empirical use of fluoroquinolones, cephalosporins, and amoxicillin-clavulanic acid has been discouraged. Piperacillin-tazobactam and aminoglycosides are carbapenem-sparing agents.

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Publication Details

Journal
IJID Regions
Published
2025-02-20
DOI
https://doi.org/10.1016/j.ijregi.2025.100605
Citations
2
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
1.18

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article

Klebsiella pneumoniae urinary tract infection: A multicentric study highlights significant regional variations in antimicrobial susceptibility across India

Jyotsna Agarwal, Shaika Farooq, Asfia Sultan, Rajeev N. Soman et al.
2 citations
IJID Regions
Antibiotic Resistance in Bacteria
1.18
article

Klebsiella pneumoniae urinary tract infection: A multicentric study highlights significant regional variations in antimicrobial susceptibility across India

Jyotsna Agarwal, Shaika Farooq, Asfia Sultan, Rajeev N. Soman, Hiba Sami, Reba Kanungo, Neelam Taneja, Shalini Malhotra, Sarita Mohapatra, Areena Hoda Siddiqui, Abdullah Balkhair, Aruna Poojary, Bhaskar Thakuria, Suneeta Meena, Meher Rizvi, Sudip Kumar Dutta, Sarman Singh, Isabella Princess, Ashish Jitendranath, Bradley J. Langford, Zaaima Al Jabri, Keith H. St. John, Renu Gur, Razan Al Zadjali, Nainaraj Ilanchezhiyan, Manodeep Sen, Sanjeev Singh, Fatima Khan, Aarti Gupta, Maria Khan, Ken Masters, Azza AL Mamari, Amal Malehi, Raman Sardana, Balvinder Mohan, Narendra Pal Singh, Pawan Kapoor, Amina Al Jardani, Sheela Devi, Mannu Jain, Vellore Ramanathan Yamunadevi, H. Tahir, Arwa Al Rajaibi, Nisha Goyal, Rugma Rajendradas
article en
2 citations

Abstract

Oral treatment options for <i>K. pneumoniae</i> cystitis are rapidly decreasing. Northern and southern India showed significant differences in antimicrobial susceptibility, highlighting the importance of local antibiograms for promoting antimicrobial stewardship. For uncomplicated cystitis, co-trimoxazole (54%) may be the empirical choice. Good susceptibility to fosfomycin was observed (89%). The empirical use of fluoroquinolones, cephalosporins, and amoxicillin-clavulanic acid has been discouraged. Piperacillin-tazobactam and aminoglycosides are carbapenem-sparing agents.

IJID RegionsVol. 14
Amrita Institute of Medical Sciences and Research Centre (IN), Indraprastha Apollo Hospitals (IN), Apollo Hospitals (IN), Central Pollution Control Board (IN), Government Medical College (IN), Jawaharlal Nehru Medical College Hospital (IN), Pondicherry Institute of Medical Sciences (IN), Aligarh Muslim University (IN), University College of Medical Sciences (IN), Patna Medical College and Hospital (IN), University of Toronto (CA), Integral University (IN), Ambedkar University Delhi (IN), Aarupadai Veedu Medical College & Hospital (IN), Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital (IN), Breach Candy Hospital (IN), Guru Teg Bahadur Hospital (IN), Sardar Vallabhbhai National Institute of Technology Surat (IN), Healthcare Infection Society (GB), Fortis Memorial Research Institute (IN), Jupiter Medical Center (US), Dr. Ram Manohar Lohia Institute of Medical Sciences (IN), Institute of Management Sciences Peshawar (PK), Sree Gokulam Medical College and Research Foundation (IN), Apollo Hospitals (IN), Ministry of Health (OM), Ministry of Agriculture and Fisheries (OM), Biological Consulting Services (United States) (US), International Foundation for Integrated Care (GB), Sultan Qaboos University Hospital (OM), Apollo Hospitals (IN), Al Nahdha Hospital (OM), Post Graduate Institute of Medical Education and Research (IN), Sultan Qaboos University (OM), Institute of Medical Sciences (IN), All India Institute of Medical Sciences (IN), Amrita Vishwa Vidyapeetham (IN)
Sultan Qaboos University
Zero hunger
Openalex Percentile: Top 25%
Antibiotic Resistance in Bacteria
1.18
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