Uncovering immune cell heterogeneity in hepatocellular carcinoma by combining single-cell RNA sequencing with T-cell receptor sequencing
We identified lymphocyte subpopulations and potential biomarker genes critical for HCC development and revealed the clonal amplification of infiltrating T cells. These data provide valuable resources for understanding the response of immune cell subsets in HCC.
Authors
- Xinyu Gu (ORCID: https://orcid.org/0000-0001-9232-8844)
- Yongxiang Yi (ORCID: https://orcid.org/0000-0002-9459-0050)
- Changhua Yi (ORCID: https://orcid.org/0009-0008-2154-1662)
- Xueying Ma (ORCID: https://orcid.org/0009-0006-5161-1073)
- Hui Dong (ORCID: https://orcid.org/0009-0008-7383-1098)
- Siyu Gu (ORCID: https://orcid.org/0000-0002-4635-2031)
- Ziyi Chen (ORCID: https://orcid.org/0000-0002-8093-8466)
- Caiyun Zhang (ORCID: https://orcid.org/0000-0002-9570-0207)
- Xiaoyue Li (ORCID: https://orcid.org/0000-0001-9149-7152)
- Jinlong Tong
- Wenxian Qian
Institutions
- Nanjing University of Chinese Medicine (CN)
- Shaoyang University (CN)
- Reproductive & Genetic Hospital CITIC-Xiangya (CN)
- Nanjing Drum Tower Hospital (CN)
- Changshu No.1 People's Hospital (CN)
- Nanjing Second Hospital (CN)
Publication Details
- Journal
- World Journal of Hepatology
- Published
- 2025-02-20
- DOI
- https://doi.org/10.4254/wjh.v17.i2.99046
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00