Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease
Sarcopenia occurs early in CLD and is a multicausal process. Relevant pathophysiologies include reduced protein synthesis, degradation of muscle proteins, arginine deficiency, a systemic pro-inflammatory and catabolic state, and muscle toxicity of bile acids. Consequently, the treatment of sarcopenia should focus both on eliminating the cause of the cholestasis and on symptomatic measures such as anti-inflammatory treatment, lowering the bile acid level, and targeted compensation of deficiencies.
Authors
- Luise Ehlers (ORCID: https://orcid.org/0000-0001-8565-0560)
- Manuela Bastian
- Elke Albrecht (ORCID: https://orcid.org/0000-0001-5974-1514)
- Robert Jaster (ORCID: https://orcid.org/0000-0002-8220-4570)
- Cornelia C. Metges (ORCID: https://orcid.org/0000-0002-9498-6020)
- Tobias Lindner (ORCID: https://orcid.org/0000-0001-7826-3132)
- Sarah L. Rohde (ORCID: https://orcid.org/0000-0003-4353-5745)
- Solvig Görs (ORCID: https://orcid.org/0009-0000-6044-5368)
- Georg Lamprecht (ORCID: https://orcid.org/0000-0003-0997-3135)
- Peggy Berlin (ORCID: https://orcid.org/0000-0001-8354-6970)
- Meike Statz (ORCID: https://orcid.org/0009-0009-8863-3593)
- Sophie Achilles
- Zeyang Li (ORCID: https://orcid.org/0000-0002-2254-2121)
- Ottavia Agrifoglio (ORCID: https://orcid.org/0000-0002-3496-3097)
- Quentin L. Sciascia (ORCID: https://orcid.org/0000-0002-5189-8450)
- Karen Friederike Gauß
- Karen Rischmüller
Institutions
- Carl von Ossietzky Universität Oldenburg (DE)
- Universitätsmedizin Greifswald (DE)
- Research Institute for Farm Animal Biology (FBN) (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13737
- Citations
- 6
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- European Social Fund