SIRT6 Ameliorates Cancer Cachexia–Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice
We found an unexpected beneficial function of SIRT6 in cancer cachexia, demonstrating that increased SIRT6 expression or activity is capable of protecting the host against cachexia-associated tissue wasting, providing a concept of future therapies for cachexia.
Authors
- Zhongchi Li (ORCID: https://orcid.org/0000-0003-4472-9218)
- Kang Yu (ORCID: https://orcid.org/0000-0002-6939-7275)
- Vivien Low (ORCID: https://orcid.org/0000-0002-8561-011X)
- Sungyun Cho (ORCID: https://orcid.org/0009-0009-2690-2268)
- Xue Li (ORCID: https://orcid.org/0009-0002-8819-8017)
- Zhao Wang (ORCID: https://orcid.org/0000-0001-7082-6922)
- Kang Xu (ORCID: https://orcid.org/0000-0002-6946-8635)
- Yu Ren (ORCID: https://orcid.org/0000-0002-8582-680X)
- Yida Wang (ORCID: https://orcid.org/0000-0001-7501-5037)
- Ying Qiu (ORCID: https://orcid.org/0000-0002-1894-9586)
- Yannan Guo
- Qingfei Liu (ORCID: https://orcid.org/0000-0002-4831-6843)
- Fang Wang (ORCID: https://orcid.org/0009-0005-0959-8955)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Cornell University (US)
- Peking Union Medical College Hospital (CN)
- Weill Cornell Medicine (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13734
- Citations
- 5
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China