Water‐Stable 2‐Pyridylboron Reagents: Pd‐Catalyzed 2‐Pyridylation Reaction of Aryl Halides
Abstract The stability of 2‐pyridylation reagents is a long‐standing issue in cross‐coupling chemistry due to hydrolysis. However, as the use of pyridine‐based pharmaceuticals continues to increase, there is a high demand for stable and reactive 2‐pyridylation reagents. Herein, a general strategy to prepare water‐stable 2‐pyridylboron reagents has been developed. The application of the water‐stable 2‐pyridylboron reagents in a neutral Suzuki–Miyaura coupling with a halide scavenger enables an efficient 2‐pyridylation reaction of aryl halides.
Authors
- Xiaofan Jia (ORCID: https://orcid.org/0000-0003-0425-5089)
- Wei Li (ORCID: https://orcid.org/0000-0001-5069-5945)
- Yu Chen (ORCID: https://orcid.org/0000-0001-9545-6761)
- Li Zhang (ORCID: https://orcid.org/0000-0001-9203-2250)
- Yingming Yao (ORCID: https://orcid.org/0000-0001-9841-3169)
- Ruihong Yuan (ORCID: https://orcid.org/0009-0003-7846-6951)
Institutions
- Soochow University (TW)
- Soochow University (CN)
Publication Details
- Journal
- Angewandte Chemie
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1002/ange.202500315
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Soochow University