Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline

This study examined the association between the latest blood pressure (BP) classification and cardiovascular disease (CVD) mortality risk, using data from 70,570 individuals across 10 Japanese cohorts. Participants were stratified by age (40-64 and 65-89 years) and antihypertensive treatment use. BP was classified according to the 2019 Japanese Society of Hypertension Guidelines. During a follow-up period of approximately 10 years, 2304 CVD deaths occurred. Cox models demonstrated that CVD mortality risk increased stepwise with the BP category, with this association being especially pronounced in patients aged 40-64 years, where the Grade I hypertension group showed the highest population-attributable fraction (PAF). When the treated participants were included in the hypertension group, the overall PAF for CVD mortality was 41.1%. Similar patterns were observed for CVD subtype mortality risk, with hypertension showing particularly high PAFs for intracerebral hemorrhage. These findings highlight the importance of early-stage prevention and management of hypertension.

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Publication Details

Journal
Hypertension Research
Published
2025-02-20
DOI
https://doi.org/10.1038/s41440-025-02151-w
Citations
10
Primary Topic
Blood Pressure and Hypertension Studies
Type
article
Field-Weighted Citation Impact
13.88
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article

Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline

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Hypertension Research
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article

Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline

Tomonori Okamura, Shizukiyo Ishikawa, Atsushi Hozawa, Katsuyuki Miura, Michihiro Satoh, Yūji Shimizu, Anna Tsutsui, Takayoshi Ohkubo, Yoshitaka Murakami, Yoshihiro Kokubo, Akiko Harada
article en
10 citations

Abstract

This study examined the association between the latest blood pressure (BP) classification and cardiovascular disease (CVD) mortality risk, using data from 70,570 individuals across 10 Japanese cohorts. Participants were stratified by age (40-64 and 65-89 years) and antihypertensive treatment use. BP was classified according to the 2019 Japanese Society of Hypertension Guidelines. During a follow-up period of approximately 10 years, 2304 CVD deaths occurred. Cox models demonstrated that CVD mortality risk increased stepwise with the BP category, with this association being especially pronounced in patients aged 40-64 years, where the Grade I hypertension group showed the highest population-attributable fraction (PAF). When the treated participants were included in the hypertension group, the overall PAF for CVD mortality was 41.1%. Similar patterns were observed for CVD subtype mortality risk, with hypertension showing particularly high PAFs for intracerebral hemorrhage. These findings highlight the importance of early-stage prevention and management of hypertension.

Hypertension ResearchVol. 48(4)
Toho University (JP), Jichi Medical University (JP), Shiga University of Medical Science (JP), Tohoku University (JP), Keio University (JP), Tohoku University Hospital (JP), National Cerebral and Cardiovascular Center (JP), Osaka Prefectural Institute of Public Health (JP), Tohoku Medical Megabank Organization (JP), Tohoku Medical and Pharmaceutical University Hospital (JP), Nagasaki University (JP), Tohoku Medical and Pharmaceutical University (JP), Teikyo University (JP)
Good health and well-being
Openalex Percentile: Top 1%
Blood Pressure and Hypertension Studies
13.88
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