IgG4-related para-testicular fibrous pseudotumor- A rare benign testicular mass mimicking malignancy: A case report and literature review

Para-testicular fibrous pseudotumors (PFP) are rare benign reactive lesions comprising of 6 % of para-testicular masses. Often misdiagnosed as malignant due to clinical and radiological overlap, they are frequently treated with aggressive surgery. We report a case of a 70-year-old male with a left inguinal swelling diagnosed post-orchidectomy as PFP. Histopathology revealed collagen-rich fibrotic tissue with lymphoplasmacytic infiltrates and IgG4-positive plasma cells. While PFP treatment requires surgical resection, testicle-sparing procedures with intraoperative frozen section assessment may prevent unnecessary orchidectomy. Further studies are needed to establish diagnostic protocols and explore the association between PFP and IgG4-related diseases.

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Publication Details

Journal
Urology Case Reports
Published
2025-02-20
DOI
https://doi.org/10.1016/j.eucr.2025.102989
Primary Topic
IgG4-Related and Inflammatory Diseases
Type
article
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article

IgG4-related para-testicular fibrous pseudotumor- A rare benign testicular mass mimicking malignancy: A case report and literature review

V Pavithra, Kashinath Singh, D Rajiv Raj, Yathwin Kanagavel et al.
Urology Case Reports
IgG4-Related and Inflammatory Diseases
article

IgG4-related para-testicular fibrous pseudotumor- A rare benign testicular mass mimicking malignancy: A case report and literature review

V Pavithra, Kashinath Singh, D Rajiv Raj, Yathwin Kanagavel, S Sanjanika
article en

Abstract

Para-testicular fibrous pseudotumors (PFP) are rare benign reactive lesions comprising of 6 % of para-testicular masses. Often misdiagnosed as malignant due to clinical and radiological overlap, they are frequently treated with aggressive surgery. We report a case of a 70-year-old male with a left inguinal swelling diagnosed post-orchidectomy as PFP. Histopathology revealed collagen-rich fibrotic tissue with lymphoplasmacytic infiltrates and IgG4-positive plasma cells. While PFP treatment requires surgical resection, testicle-sparing procedures with intraoperative frozen section assessment may prevent unnecessary orchidectomy. Further studies are needed to establish diagnostic protocols and explore the association between PFP and IgG4-related diseases.

Urology Case ReportsVol. 59
Sri Ramachandra Institute of Higher Education and Research (IN)
Good health and well-being
Openalex Percentile: Top 95%
IgG4-Related and Inflammatory Diseases
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