The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes
In summary, ZFP36L2 bound to and degraded viral RNA through the XRN1-mediated RNA decay pathway in the RCs, thereby inhibiting flavivirus replication. These findings provide valuable insights into the diverse antiviral mechanisms of the ZFP36-like family of proteins in the innate immune response against flavivirus infection.
Authors
- Zih-Ping Chen
- Ching‐Len Liao
- Bingcheng Liu (ORCID: https://orcid.org/0000-0002-3147-3607)
- Ren-Jye Lin (ORCID: https://orcid.org/0000-0003-4196-946X)
- Li-Hsiung Lin
- Pin-Chen Ko
Institutions
- National Health Research Institutes (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12929-025-01122-0
- Citations
- 3
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Health Research Institutes