miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting
This study is the first to uncover a novel regulatory pathway where c-Jun acts as a transcriptional repressor of miR-193b-3p, leading to PRNP upregulation, which promotes lung cancer migration and invasion. This previously unrecognized c-Jun-miR-193b-3p-PrPc axis also provides valuable insights for the potential development of new therapeutic strategies against lung cancer metastasis through RNA-targeting technology.
Authors
- Mei‐Yu Chen (ORCID: https://orcid.org/0000-0002-5765-9178)
- Yi‐Chen Yeh (ORCID: https://orcid.org/0000-0002-6442-4967)
- Che-Wei Liu
- Chao‐Wei Chiang (ORCID: https://orcid.org/0000-0003-0629-7848)
- Ching‐Yu Lin (ORCID: https://orcid.org/0000-0001-8269-797X)
- Hsiang‐Ling Ho
- Shin-Chih Lin
- Teh-Ying Chou
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Medical University Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12929-025-01121-1
- Citations
- 8
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- Shanghai Educational Development Foundation
- Taipei Medical University
- National Taiwan University
- Taipei Veterans General Hospital
- National Science and Technology Council