A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway
Our results revealed that the DENV NS1 amino acid substitution affects the NS1 ability in immune evasion, which may contribute to the largest dengue outbreak in Taiwan since the 1990s.
Authors
- Sheng-Hsuan Wang
- Pin Ling (ORCID: https://orcid.org/0000-0002-8894-5433)
- Chiao-Hsuan Chao (ORCID: https://orcid.org/0000-0003-0114-0948)
- Shu Wan (ORCID: https://orcid.org/0000-0002-0186-6274)
- Trai‐Ming Yeh (ORCID: https://orcid.org/0000-0003-3172-7432)
- Justin Jang Hann Chu (ORCID: https://orcid.org/0000-0002-1673-6819)
- Hée J
- Dayna Cheng
- Jen‐Ren Wang (ORCID: https://orcid.org/0000-0002-4127-4046)
- Yu‐Hong Chen (ORCID: https://orcid.org/0009-0009-8356-0153)
- Sheng-Wen Huang (ORCID: https://orcid.org/0000-0002-9127-7616)
- Chih‐Peng Chang (ORCID: https://orcid.org/0000-0002-0212-5048)
Institutions
- National Health Research Institutes (TW)
- National University of Singapore (SG)
- Mackay Medical University (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-02-20
- DOI
- https://doi.org/10.1186/s12929-024-01116-4
- Citations
- 6
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 11.27
Funders
- National Health Research Institutes
- National Cheng Kung University Hospital
- National Cheng Kung University
- National Science and Technology Council